In college a group of four young men establish a tradition: every year, they come together for a week-long trip in search of adventure and distraction. They travel around the world to go hiking, biking, or kayaking. They call it their Man Mission, a sacred ritual dedicated to new experiences and friendship.

In the course of their travels, they hitch a ride with drug dealers in New Zealand, down kava shots on Fijian beaches, come face-to-face with a roaring lion in South Africa, luxuriate in a resort intended only for Vietnamese Communist officials, trek to Machu Picchu, and go ice climbing in Iceland.