With the help of her husband Larry, a computer analyst, Deborah tracks the epicenter to New York City, from which the infection is already bursting forth. And, as years pass, despite hundreds of laboratories at work on it, the microbe continues to overrun borders and envelop the Earth. With Science unable to stop it, and the contagion rippling worldwide in an AIDS-like pandemic, how will society cope in an increasingly female world?

Unquestionably, some changes are inevitable. Companies hire more women; who assume more leadership positions, replacing the male hierarchy with their own female style of management, to great success. Among the younger generation, monogamy is increasingly replaced by polygamy. Wars decrease. Crime falls. Football attendance is down. Ballet is up.

“Y” follows three New York City families for an entire generation, each with its own story. The blue-collar husband proves unable to deal with a wife who has become the major bread-winner. The yuppie husband does well in his career but cannot resist the temptations of a workplace with limitless young women. His wife, turned off from men entirely, will leave him and become a force to reckon with in her own right. And, along the way, the children of all three families struggle to find mates and to secure their own places in this new, topsy-turvy world.

At once a fast-paced thriller of a gripping race for a cure, a speculative tale about a futuristic society, and a comic battle between the sexes, “Y” is, above all, the story of real people caught up in a society they no longer recognize.